Poly(ADP-ribosyl)ation basally activated by DNA strand breaks reflects glutamate–nitric oxide neurotransmission

Poly(ADP-ribose) polymerase (PARP) transfers ADP ribose groups from NAD(+) to nuclear proteins after activation by DNA strand breaks. PARP overactivation by massive DNA damage causes cell death via NAD(+) and ATP depletion. Heretofore, PARP has been thought to be inactive under basal physiologic con...

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Detalhes bibliográficos
Main Authors: Pieper, Andrew A., Blackshaw, Seth, Clements, Emily E., Brat, Daniel J., Krug, David K., White, Alison J., Pinto-Garcia, Patricia, Favit, Antonella, Conover, Jill R., Snyder, Solomon H., Verma, Ajay
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC26524/
https://ncbi.nlm.nih.gov/pubmed/10677544
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