Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes

Streptozotocin (STZ) selectively destroys insulin-producing beta islet cells of the pancreas providing a model of type I diabetes. Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme whose overactivation by DNA strand breaks depletes its substrate NAD(+) and then ATP, leading to cellular death fr...

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Detalhes bibliográficos
Main Authors: Pieper, Andrew A., Brat, Daniel J., Krug, David K., Watkins, Crystal C., Gupta, Alok, Blackshaw, Seth, Verma, Ajay, Wang, Zhao-Qi, Snyder, Solomon H.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC15894/
https://ncbi.nlm.nih.gov/pubmed/10077636
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