A suppressor screen in mouse Mecp2 implicates cholesterol metabolism in Rett Syndrome

Mutations in methyl CpG binding protein 2 (MECP2) cause Rett Syndrome, the most severe autism spectrum disorder. Re-expressing Mecp2 in symptomatic Mecp2 null mice dramatically improves function and longevity, providing hope that therapeutic intervention is possible in humans. To identify pathways i...

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Bibliografski detalji
Glavni autori: Buchovecky, Christie M., Turley, Stephen D., Brown, Hannah M., Kyle, Stephanie M., McDonald, Jeffrey G., Liu, Benny, Pieper, Andrew A., Huang, Wenhui, Katz, David M., Russell, David W., Shendure, Jay, Justice, Monica J.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837522/
https://ncbi.nlm.nih.gov/pubmed/23892605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2714
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