P7C3 Neuroprotective Chemicals Function by Activating the Rate-limiting Enzyme in NAD Salvage

The P7C3 class of aminopropyl carbazole chemicals fosters the survival of neurons in a variety of rodent models of neurodegeneration or nerve cell injury. To uncover its mechanism of action, an active derivative of P7C3 was modified to contain both a benzophenone for photo-crosslinking and an alkyne...

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Bibliografiske detaljer
Main Authors: Wang, Gelin, Han, Ting, Nijhawan, Deepak, Theodoropoulos, Pano, Naidoo, Jacinth, Yadavalli, Sivaramakrishnan, Mirzaei, Hamid, Pieper, Andrew A., Ready, Joseph M., McKnight, Steven L.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4163014/
https://ncbi.nlm.nih.gov/pubmed/25215490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.07.040
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