Discovery of a Pro-neurogenic, Neuroprotective Chemical

An in vivo screen was performed in search of chemicals capable of enhancing neuron formation in the hippocampus of adult mice. Eight of 1,000 small molecules tested enhanced neuron formation in the subgranular zone of the dentate gyrus. Among these was an aminopropyl carbazole, designated P7C3, endo...

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Detalhes bibliográficos
Main Authors: Pieper, Andrew A., Xie, Shanhai, Capota, Ema, Estill, Sandi Jo, Zhong, Jeannie, Long, Jeffrey M., Becker, Ginger L., Huntington, Paula, Goldman, Shauna E., Shen, Ching-Han, Capota, Maria, Britt, Jeremiah K., Kotti, Tiina, Ure, Kerstin, Brat, Daniel J., Williams, Noelle S., MacMillan, Karen S., Naidoo, Jacinth, Melito, Lisa, Hsieh, Jenny, De Brabander, Jef, Ready, Joseph M., McKnight, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930815/
https://ncbi.nlm.nih.gov/pubmed/20603013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.06.018
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