Improvement of Pharmacological Properties of Irreversible Thyroid Receptor Coactivator Binding Inhibitors

gan Hwang, Jong Yeon, Arnold, Leggy A., Zhu, Fangyi, Kosinski, Aaron, Mangano, Thomas J., Setola, Vincent, Roth, Bryan L., Guy, R. Kiplin
Cyhoeddwyd 2009

Structure based discovery of new antagonist and biased agonist chemotypes for the Kappa Opioid Receptor

gan Zheng, Zhong, Huang, Xi-Ping, Mangano, Thomas J., Zuo, Rodger, Chen, Xin, Zaidi, Saheem, Roth, Bryan L., Stevens, Raymond C., Katritch, Vsevolod
Cyhoeddwyd yn J Med Chem (2017)

Discovery of a Neuroprotective Chemical, (S)-N-(3-(3,6-Dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(−)-P7C3-S243], with Improved Druglike Properties

gan Naidoo, Jacinth, De Jesus-Cortes, Hector, Huntington, Paula, Estill, Sandi, Morlock, Lorraine K., Starwalt, Ruth, Mangano, Thomas J., Williams, Noelle S., Pieper, Andrew A., Ready, Joseph M.
Cyhoeddwyd 2014

Fentanyl-related designer drugs W-18 and W-15 lack appreciable opioid activity in vitro and in vivo

gan Huang, Xi-Ping, Che, Tao, Mangano, Thomas J., Le Rouzic, Valerie, Pan, Ying-Xian, Cameron, Michael D., Baumann, Michael H., Pasternak, Gavril W., Roth, Bryan L.
Cyhoeddwyd yn JCI Insight (2017)

Structural basis for Smoothened receptor modulation and chemoresistance to anti-cancer drugs

gan Wang, Chong, Wu, Huixian, Evron, Tama, Vardy, Eyal, Han, Gye Won, Huang, Xi-Ping, Hufeisen, Sandy J., Mangano, Thomas J., Urban, Dan J., Katritch, Vsevolod, Cherezov, Vadim, Caron, Marc G., Roth, Bryan L., Stevens, Raymond C.
Cyhoeddwyd 2014

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65

gan Huang, Xi-Ping, Karpiak, Joel, Kroeze, Wesley K., Zhu, Hu, Chen, Xin, Moy, Sheryl S., Saddoris, Kara A., Nikolova, Viktoriya, Farrell, Martilias S., Wang, Sheng, Mangano, Thomas J., Deshpande, Deepak A., Jiang, Alice, Penn, Raymond B., Jin, Jian, Koller, Beverly H., Kenakin, Terry, Shoichet, Brian K., Roth, Bryan L.
Cyhoeddwyd yn Nature (2015)

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

gan Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Liu, Feng, Rival-Gervier, Sylvie, Allali-Hassani, Abdellah, Labrie, Viviane, Wigle, Tim J, Dimaggio, Peter A, Wasney, Gregory A, Siarheyeva, Alena, Dong, Aiping, Tempel, Wolfram, Wang, Sun-Chong, Chen, Xin, Chau, Irene, Mangano, Thomas J, Huang, Xi-ping, Simpson, Catherine D, Pattenden, Samantha G, Norris, Jacqueline L, Kireev, Dmitri B, Tripathy, Ashutosh, Edwards, Aled, Roth, Bryan L, Janzen, William P, Garcia, Benjamin A, Petronis, Arturas, Ellis, James, Brown, Peter J, Frye, Stephen V, Arrowsmith, Cheryl H, Jin, Jian
Cyhoeddwyd 2011