Improvement of Pharmacological Properties of Irreversible Thyroid Receptor Coactivator Binding Inhibitors

Por Hwang, Jong Yeon, Arnold, Leggy A., Zhu, Fangyi, Kosinski, Aaron, Mangano, Thomas J., Setola, Vincent, Roth, Bryan L., Guy, R. Kiplin
Publicado em 2009

Discovery of a Neuroprotective Chemical, (S)-N-(3-(3,6-Dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(−)-P7C3-S243], with Improved Druglike Properties

Por Naidoo, Jacinth, De Jesus-Cortes, Hector, Huntington, Paula, Estill, Sandi, Morlock, Lorraine K., Starwalt, Ruth, Mangano, Thomas J., Williams, Noelle S., Pieper, Andrew A., Ready, Joseph M.
Publicado em 2014

Structural basis for Smoothened receptor modulation and chemoresistance to anti-cancer drugs

Por Wang, Chong, Wu, Huixian, Evron, Tama, Vardy, Eyal, Han, Gye Won, Huang, Xi-Ping, Hufeisen, Sandy J., Mangano, Thomas J., Urban, Dan J., Katritch, Vsevolod, Cherezov, Vadim, Caron, Marc G., Roth, Bryan L., Stevens, Raymond C.
Publicado em 2014

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65

Por Huang, Xi-Ping, Karpiak, Joel, Kroeze, Wesley K., Zhu, Hu, Chen, Xin, Moy, Sheryl S., Saddoris, Kara A., Nikolova, Viktoriya, Farrell, Martilias S., Wang, Sheng, Mangano, Thomas J., Deshpande, Deepak A., Jiang, Alice, Penn, Raymond B., Jin, Jian, Koller, Beverly H., Kenakin, Terry, Shoichet, Brian K., Roth, Bryan L.
Publicado no Nature (2015)

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

Por Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Liu, Feng, Rival-Gervier, Sylvie, Allali-Hassani, Abdellah, Labrie, Viviane, Wigle, Tim J, Dimaggio, Peter A, Wasney, Gregory A, Siarheyeva, Alena, Dong, Aiping, Tempel, Wolfram, Wang, Sun-Chong, Chen, Xin, Chau, Irene, Mangano, Thomas J, Huang, Xi-ping, Simpson, Catherine D, Pattenden, Samantha G, Norris, Jacqueline L, Kireev, Dmitri B, Tripathy, Ashutosh, Edwards, Aled, Roth, Bryan L, Janzen, William P, Garcia, Benjamin A, Petronis, Arturas, Ellis, James, Brown, Peter J, Frye, Stephen V, Arrowsmith, Cheryl H, Jin, Jian
Publicado em 2011