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Improvement of Pharmacological Properties of Irreversible Thyroid Receptor Coactivator Binding Inhibitors
[Image: see text] We have previously reported the discovery and preliminary structure activity relationships of a series of β-aminoketones that disrupt the binding of coactivators to TR. However, the most active compounds had moderate inhibitory potency and relatively high cytotoxicity, resulting in...
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| Principais autores: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2753520/ https://ncbi.nlm.nih.gov/pubmed/19469546 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9002704 |
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