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Improvement of Pharmacological Properties of Irreversible Thyroid Receptor Coactivator Binding Inhibitors

[Image: see text] We have previously reported the discovery and preliminary structure activity relationships of a series of β-aminoketones that disrupt the binding of coactivators to TR. However, the most active compounds had moderate inhibitory potency and relatively high cytotoxicity, resulting in...

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書誌詳細
主要な著者: Hwang, Jong Yeon, Arnold, Leggy A., Zhu, Fangyi, Kosinski, Aaron, Mangano, Thomas J., Setola, Vincent, Roth, Bryan L., Guy, R. Kiplin
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753520/
https://ncbi.nlm.nih.gov/pubmed/19469546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9002704
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