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Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPT's) as thyroid hormone receptor-coactivator interaction inhibitors

We previously identified a series of methylsulfonylnitrobenzoates (MSNB's) that block the interaction of the thyroid hormone receptor with its coactivators. MSNB's inhibits coactivator binding through irreversibly modifying cysteine 298 of thyroid hormone receptor (TR). Although MSNB'...

詳細記述

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書誌詳細
主要な著者: Hwang, Jong Yeon, Attia, Ramy R., Zhu, Fangyi, Yang, Lei, Lemoff, Andrew, Jeffries, Cynthia, Connelly, Michele C., Guy, R. Kiplin
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308170/
https://ncbi.nlm.nih.gov/pubmed/22324546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201546m
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