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Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPT's) as thyroid hormone receptor-coactivator interaction inhibitors
We previously identified a series of methylsulfonylnitrobenzoates (MSNB's) that block the interaction of the thyroid hormone receptor with its coactivators. MSNB's inhibits coactivator binding through irreversibly modifying cysteine 298 of thyroid hormone receptor (TR). Although MSNB'...
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主要な著者: | , , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
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2012
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オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3308170/ https://ncbi.nlm.nih.gov/pubmed/22324546 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201546m |
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