Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPT's) as thyroid hormone receptor-coactivator interaction inhibitors

We previously identified a series of methylsulfonylnitrobenzoates (MSNB's) that block the interaction of the thyroid hormone receptor with its coactivators. MSNB's inhibits coactivator binding through irreversibly modifying cysteine 298 of thyroid hormone receptor (TR). Although MSNB'...

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Bibliographische Detailangaben
Hauptverfasser: Hwang, Jong Yeon, Attia, Ramy R., Zhu, Fangyi, Yang, Lei, Lemoff, Andrew, Jeffries, Cynthia, Connelly, Michele C., Guy, R. Kiplin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308170/
https://ncbi.nlm.nih.gov/pubmed/22324546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201546m
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