Synthesis and evaluation of sulfonylnitrophenylthiazoles (SNPT's) as thyroid hormone receptor-coactivator interaction inhibitors

We previously identified a series of methylsulfonylnitrobenzoates (MSNB's) that block the interaction of the thyroid hormone receptor with its coactivators. MSNB's inhibits coactivator binding through irreversibly modifying cysteine 298 of thyroid hormone receptor (TR). Although MSNB'...

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Autores principales: Hwang, Jong Yeon, Attia, Ramy R., Zhu, Fangyi, Yang, Lei, Lemoff, Andrew, Jeffries, Cynthia, Connelly, Michele C., Guy, R. Kiplin
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308170/
https://ncbi.nlm.nih.gov/pubmed/22324546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201546m
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