Unesterified Cholesterol Accumulation in Late Endosomes/Lysosomes Causes Neurodegeneration and Is Prevented by Driving Cholesterol Export from This Compartment

While unesterified cholesterol (C) is essential for remodeling neuronal plasma membranes, its role in certain neurodegenerative disorders remains poorly defined. Uptake of sterol from pericellular fluid requires processing that involves two lysosomal proteins, lysosomal acid lipase, which hydrolyzes...

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Detalhes bibliográficos
Main Authors: Aqul, Amal, Liu, Benny, Ramirez, Charina M., Pieper, Andrew A., Estill, Sandi Jo, Burns, Dennis K., Liu, Bing, Repa, Joyce J., Turley, Stephen D., Dietschy, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134878/
https://ncbi.nlm.nih.gov/pubmed/21697390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1317-11.2011
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