Unesterified Cholesterol Accumulation in Late Endosomes/Lysosomes Causes Neurodegeneration and Is Prevented by Driving Cholesterol Export from This Compartment

While unesterified cholesterol (C) is essential for remodeling neuronal plasma membranes, its role in certain neurodegenerative disorders remains poorly defined. Uptake of sterol from pericellular fluid requires processing that involves two lysosomal proteins, lysosomal acid lipase, which hydrolyzes...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Aqul, Amal, Liu, Benny, Ramirez, Charina M., Pieper, Andrew A., Estill, Sandi Jo, Burns, Dennis K., Liu, Bing, Repa, Joyce J., Turley, Stephen D., Dietschy, John M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2011
Schlagworte:
Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3134878/
https://ncbi.nlm.nih.gov/pubmed/21697390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1317-11.2011
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge