Hepatic entrapment of esterified cholesterol drives continual expansion of whole body sterol pool in lysosomal acid lipase-deficient mice

Samankaltaisia teoksia

• Deletion of sterol O-acyltransferase 2 (SOAT2) function in mice deficient in lysosomal acid lipase (LAL) dramatically reduces esterified cholesterol sequestration in the small intestine and liver
  Tekijä: Lopez, Adam M., et al.
  Julkaistu: (2014)
• Unesterified Cholesterol Accumulation in Late Endosomes/Lysosomes Causes Neurodegeneration and Is Prevented by Driving Cholesterol Export from This Compartment
  Tekijä: Aqul, Amal, et al.
  Julkaistu: (2011)
• Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations
  Tekijä: Ramirez, Charina M., et al.
  Julkaistu: (2011)
• Niemann-Pick C1-deficient mice lacking sterol O-acyltransferase 2 have less hepatic cholesterol entrapment and improved liver function
  Tekijä: Lopez, Adam M., et al.
  Julkaistu: (2018)
• Inhibiting intestinal NPC1L1 activity prevents diet-induced increase in biliary cholesterol in Golden Syrian hamsters
  Tekijä: Valasek, Mark A., et al.
  Julkaistu: (2008)