Inhibiting intestinal NPC1L1 activity prevents diet-induced increase in biliary cholesterol in Golden Syrian hamsters

Niemann-Pick C1-like 1 (NPC1L1) facilitates the uptake of sterols into the enterocyte and is the target of the novel cholesterol absorption inhibitor, ezetimibe. These studies used the Golden Syrian hamster as a model to delineate the changes in the relative mRNA expression of NPC1L1 and other prote...

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Библиографические подробности
Главные авторы: Valasek, Mark A., Repa, Joyce J., Quan, Gang, Dietschy, John M., Turley, Stephen D.
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2008
Предметы:
Liver and Biliary Tract
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575918/
https://ncbi.nlm.nih.gov/pubmed/18718997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.90372.2008
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