Liver X Receptor Activation Enhances Cholesterol Loss from the Brain, Decreases Neuroinflammation, and Increases Survival of the NPC1 Mouse

Although cholesterol is a major component of the CNS, there is little information on how or whether a change in sterol flux across the blood–brain barrier might alter neurodegeneration. In Niemann-Pick type C (NPC) disease, a mutation in NPC1 protein causes unesterified cholesterol to accumulate in...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Repa, Joyce J., Li, Hao, Frank-Cannon, Tamy C., Valasek, Mark A., Turley, Stephen D., Tansey, Malú G., Dietschy, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673433/
https://ncbi.nlm.nih.gov/pubmed/18160655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4823-07.2007
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