Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages

The glucocorticoid (GC) receptor (GR) suppresses inflammation by activating anti-inflammatory and repressing pro-inflammatory genes. GR-interacting protein-1 (GRIP1) is a GR corepressor in macrophages, however, whether GRIP1 mediates GR-activated transcription, and what dictates its coactivator vers...

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Udgivet i:Nat Commun
Main Authors: Rollins, David A., Kharlyngdoh, Joubert B., Coppo, Maddalena, Tharmalingam, Bowranigan, Mimouna, Sanda, Guo, Ziyi, Sacta, Maria A., Pufall, Miles A., Fisher, Robert P., Hu, Xiaoyu, Chinenov, Yurii, Rogatsky, Inez
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700924/
https://ncbi.nlm.nih.gov/pubmed/29170386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01569-2
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