Transcription cofactor GRIP1 differentially affects myeloid cell–driven neuroinflammation and response to IFN-β therapy

Macrophages (MФ) and microglia (MG) are critical in the pathogenesis of multiple sclerosis (MS) and its mouse model, experimental autoimmune encephalomyelitis (EAE). Glucocorticoids (GCs) and interferon β (IFN-β) are frontline treatments for MS, and disrupting each pathway in mice aggravates EAE. Gl...

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Veröffentlicht in:J Exp Med
Hauptverfasser: Mimouna, Sanda, Rollins, David A., Shibu, Gayathri, Tharmalingam, Bowranigan, Deochand, Dinesh K., Chen, Xi, Oliver, David, Chinenov, Yurii, Rogatsky, Inez
Format: Artigo
Sprache:Inglês
Veröffentlicht: Rockefeller University Press 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555412/
https://ncbi.nlm.nih.gov/pubmed/33045064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20192386
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