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Gene-specific mechanisms direct glucocorticoid-receptor-driven repression of inflammatory response genes in macrophages
The glucocorticoid receptor (GR) potently represses macrophage-elicited inflammation, however, the underlying mechanisms remain obscure. Our genome-wide analysis in mouse macrophages reveals that pro-inflammatory paused genes, activated via global negative elongation factor (NELF) dissociation and R...
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| Pubblicato in: | eLife |
|---|---|
| Autori principali: | , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5821458/ https://ncbi.nlm.nih.gov/pubmed/29424686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34864 |
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