Gene-specific mechanisms direct glucocorticoid-receptor-driven repression of inflammatory response genes in macrophages

The glucocorticoid receptor (GR) potently represses macrophage-elicited inflammation, however, the underlying mechanisms remain obscure. Our genome-wide analysis in mouse macrophages reveals that pro-inflammatory paused genes, activated via global negative elongation factor (NELF) dissociation and R...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Sacta, Maria A, Tharmalingam, Bowranigan, Coppo, Maddalena, Rollins, David A, Deochand, Dinesh K, Benjamin, Bradley, Yu, Li, Zhang, Bin, Hu, Xiaoyu, Li, Rong, Chinenov, Yurii, Rogatsky, Inez
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Chromosomes and Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821458/
https://ncbi.nlm.nih.gov/pubmed/29424686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.34864
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