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Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles
Targeting noncatalytic cysteine residues with irreversible acrylamide-based inhibitors is a powerful approach for enhancing pharmacological potency and selectivity. Nevertheless, concerns about off-target modification motivate the development of reversible cysteine-targeting strategies. Here we show...
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| Main Authors: | , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2012
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3657615/ https://ncbi.nlm.nih.gov/pubmed/22466421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.925 |
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