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Electrophilic Fragment-Based Design of Reversible Covalent Kinase Inhibitors
Fragment-based ligand design and covalent targeting of noncatalytic cysteines have been employed to develop potent and selective kinase inhibitors. Here, we combine these approaches, starting with a panel of low-molecular weight, heteroaryl-susbstituted cyanoacrylamides, which we have previously sho...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3665406/ https://ncbi.nlm.nih.gov/pubmed/23540679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja401221b |
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