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Targeting Protein Kinases with Selective and Semi-Promiscuous Covalent Inhibitors

Protein kinase inhibitors are an important class of therapeutics. In addition, selective kinase inhibitors can often reveal unexpected biological insights, augmenting genetic approaches and playing a decisive role in preclinical target validation studies. Nevertheless, developing protein kinase inhi...

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Detalhes bibliográficos
Publicado no:Methods Enzymol
Main Authors: Miller, Rand M., Taunton, Jack
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4265651/
https://ncbi.nlm.nih.gov/pubmed/25399643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/B978-0-12-397918-6.00004-5
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