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Design of Reversible, Cysteine-Targeted Michael Acceptors Guided by Kinetic and Computational Analysis
[Image: see text] Electrophilic probes that covalently modify a cysteine thiol often show enhanced pharmacological potency and selectivity. Although reversible Michael acceptors have been reported, the structural requirements for reversibility are poorly understood. Here, we report a novel class of...
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| Main Authors: | , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4160273/ https://ncbi.nlm.nih.gov/pubmed/25153195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja505194w |
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