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Prolonged and tunable residence time using reversible covalent kinase inhibitors
Drugs with prolonged, on-target residence time often show superior efficacy, yet general strategies for optimizing drug-target residence time are lacking. Here, we demonstrate progress toward this elusive goal by targeting a noncatalytic cysteine in Bruton's tyrosine kinase (BTK) with reversibl...
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| Vydáno v: | Nat Chem Biol |
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| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4472506/ https://ncbi.nlm.nih.gov/pubmed/26006010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1817 |
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