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Tunable Methacrylamides for Covalent Ligand Directed Release Chemistry

[Image: see text] Targeted covalent inhibitors are an important class of drugs and chemical probes. However, relatively few electrophiles meet the criteria for successful covalent inhibitor design. Here we describe α-substituted methacrylamides as a new class of electrophiles suitable for targeted c...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Reddi, Rambabu N., Resnick, Efrat, Rogel, Adi, Rao, Boddu Venkateswara, Gabizon, Ronen, Goldenberg, Kim, Gurwicz, Neta, Zaidman, Daniel, Plotnikov, Alexander, Barr, Haim, Shulman, Ziv, London, Nir
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8041284/
https://ncbi.nlm.nih.gov/pubmed/33761747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c10644
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