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Tunable Methacrylamides for Covalent Ligand Directed Release Chemistry
[Image: see text] Targeted covalent inhibitors are an important class of drugs and chemical probes. However, relatively few electrophiles meet the criteria for successful covalent inhibitor design. Here we describe α-substituted methacrylamides as a new class of electrophiles suitable for targeted c...
Gardado en:
| Publicado en: | J Am Chem Soc |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Chemical
Society
2021
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8041284/ https://ncbi.nlm.nih.gov/pubmed/33761747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c10644 |
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