Targeting Interleukin-2-inducible T-cell Kinase (ITK) and Resting Lymphocyte Kinase (RLK) Using a Novel Covalent Inhibitor PRN694

Interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK or TXK) are essential mediators of intracellular signaling in both normal and neoplastic T-cells and natural killer (NK) cells. Thus, ITK and RLK inhibitors have therapeutic potential in a number of human autoimmune, infl...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zhong, Yiming, Dong, Shuai, Strattan, Ethan, Ren, Li, Butchar, Jonathan P., Thornton, Kelsey, Mishra, Anjali, Porcu, Pierluigi, Bradshaw, J. Michael, Bisconte, Angelina, Owens, Timothy D., Verner, Erik, Brameld, Ken A., Funk, Jens Oliver, Hill, Ronald J., Johnson, Amy J., Dubovsky, Jason A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358234/
https://ncbi.nlm.nih.gov/pubmed/25593320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.614891
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados