2-Sulfonyl pyridines as tunable, cysteine-reactive electrophiles

The emerging use of covalent ligands as chemical probes and drugs would benefit from an expanded repertoire of cysteine-reactive electrophiles for efficient and diverse targeting of the proteome. Here we use the endogenous electrophile sensor of mammalian cells — the KEAP1-NRF2 pathway — to discover...

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Bibliografiset tiedot
Julkaisussa:J Am Chem Soc
Päätekijät: Zambaldo, Claudio, Vinogradova, Ekaterina V., Qi, Xiaotian, Iaconelli, Jonathan, Suciu, Radu M., Koh, Minseob, Senkane, Kristine, Chadwick, Stormi R., Sanchez, Brittany B., Chen, Jason S., Chatterjee, Arnab K., Liu, Peng, Schultz, Peter G., Cravatt, Benjamin F., Bollong, Michael J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7365253/
https://ncbi.nlm.nih.gov/pubmed/32302104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c02721
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