2-Sulfonyl pyridines as tunable, cysteine-reactive electrophiles

The emerging use of covalent ligands as chemical probes and drugs would benefit from an expanded repertoire of cysteine-reactive electrophiles for efficient and diverse targeting of the proteome. Here we use the endogenous electrophile sensor of mammalian cells — the KEAP1-NRF2 pathway — to discover...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Zambaldo, Claudio, Vinogradova, Ekaterina V., Qi, Xiaotian, Iaconelli, Jonathan, Suciu, Radu M., Koh, Minseob, Senkane, Kristine, Chadwick, Stormi R., Sanchez, Brittany B., Chen, Jason S., Chatterjee, Arnab K., Liu, Peng, Schultz, Peter G., Cravatt, Benjamin F., Bollong, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7365253/
https://ncbi.nlm.nih.gov/pubmed/32302104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c02721
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