The proteome-wide potential for reversible covalency at cysteine

Reversible covalency, achieved with, for instance, highly electron-deficient olefins, offers a compelling strategy to design chemical probes and drugs that benefit from the sustained target engagement afforded by irreversible compounds, while avoiding permanent protein modification that persists fol...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Senkane, Kristine, Vinogradova, Ekaterina V., Suciu, Radu M., Crowley, Vincent M., Zaro, Balyn W., Bradshaw, J. Michael, Brameld, Ken A., Cravatt, Benjamin F.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6684851/
https://ncbi.nlm.nih.gov/pubmed/31222866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201905829
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