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The proteome-wide potential for reversible covalency at cysteine
Reversible covalency, achieved with, for instance, highly electron-deficient olefins, offers a compelling strategy to design chemical probes and drugs that benefit from the sustained target engagement afforded by irreversible compounds, while avoiding permanent protein modification that persists fol...
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| Publicado en: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6684851/ https://ncbi.nlm.nih.gov/pubmed/31222866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201905829 |
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