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Chemical proteomic identification of functional cysteines with atypical electrophile reactivities

Cysteine-directed covalent ligands have emerged as a versatile category of chemical probes and drugs that leverage thiol nucleophilicity to form permanent adducts with proteins of interest. Understanding the scope of cysteines that can be targeted by covalent ligands, as well as the types of electro...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Tetrahedron Lett
Päätekijät: Litwin, Kevin, Crowley, Vincent M., Suciu, Radu M., Boger, Dale L., Cravatt, Benjamin F.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2021
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7996670/
https://ncbi.nlm.nih.gov/pubmed/33776155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2021.152861
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