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Proteome-wide covalent ligand discovery in native biological systems
Small molecules are powerful tools for investigating protein function and can serve as leads for new therapeutics. Most human proteins, however, lack small-molecule ligands, and entire protein classes are considered “undruggable” (1,2). Fragment-based ligand discovery (FBLD) can identify small-molec...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4919207/ https://ncbi.nlm.nih.gov/pubmed/27309814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature18002 |
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