Proteome-wide covalent ligand discovery in native biological systems

Small molecules are powerful tools for investigating protein function and can serve as leads for new therapeutics. Most human proteins, however, lack small-molecule ligands, and entire protein classes are considered “undruggable” (1,2). Fragment-based ligand discovery (FBLD) can identify small-molec...

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Bibliografski detalji
Izdano u:Nature
Glavni autori: Backus, Keriann M., Correia, Bruno E., Lum, Kenneth M., Forli, Stefano, Horning, Benjamin D., González-Páez, Gonzalo E., Chatterjee, Sandip, Lanning, Bryan R., Teijaro, John R., Olson, Arthur J., Wolan, Dennis W., Cravatt, Benjamin F.
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919207/
https://ncbi.nlm.nih.gov/pubmed/27309814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature18002
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