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Global profiling of lysine reactivity and ligandability in the human proteome
Nucleophilic amino acids make important contributions to protein function, including performing key roles in catalysis and serving as sites for post-translational modification. Electrophilic groups that target amino-acid nucleophiles have been used to create covalent ligands and drugs, but have, so...
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| Pubblicato in: | Nat Chem |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5726523/ https://ncbi.nlm.nih.gov/pubmed/29168484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2826 |
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