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Global profiling of lysine reactivity and ligandability in the human proteome
Nucleophilic amino acids make important contributions to protein function, including performing key roles in catalysis and serving as sites for post-translational modification. Electrophilic groups that target amino-acid nucleophiles have been used to create covalent ligands and drugs, but have, so...
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| Yayımlandı: | Nat Chem |
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| Asıl Yazarlar: | , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5726523/ https://ncbi.nlm.nih.gov/pubmed/29168484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2826 |
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