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Functionalized Scout Fragments for Site-Specific Covalent Ligand Discovery and Optimization
[Image: see text] Covalent ligands are a versatile class of chemical probes and drugs that can target noncanonical sites on proteins and display differentiated pharmacodynamic properties. Chemical proteomic methods have been introduced that leverage electrophilic fragments to globally profile the co...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | ACS Cent Sci |
|---|---|
| Prif Awduron: | , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
American Chemical Society
2021
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| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8155467/ https://ncbi.nlm.nih.gov/pubmed/34056091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.0c01336 |
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