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Ligand and Target Discovery by Fragment-Based Screening in Human Cells
Advances in the synthesis and screening of small-molecule libraries have accelerated the discovery of chemical probes for studying biological processes. Still, only a small fraction of the human proteome has chemical ligands. Here, we describe a platform that marries fragment-based ligand discovery...
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| Publicado no: | Cell |
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| Principais autores: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5632530/ https://ncbi.nlm.nih.gov/pubmed/28111073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.12.029 |
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