A naturally occuring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms

In addition to guiding proteins to defined genomic loci, DNA can act as an allosteric ligand that influences protein structure and activity. Here we compared genome-wide binding, transcriptional regulation, and, using NMR, the conformation of two glucocorticoid receptor (GR) isoforms that differ by...

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Autors principals: Thomas-Chollier, Morgane, Watson, Lisa C., Cooper, Samantha B., Pufall, Miles A., Liu, Jennifer S., Borzym, Katja, Vingron, Martin, Yamamoto, Keith R., Meijsing, Sebastiaan H.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816441/
https://ncbi.nlm.nih.gov/pubmed/24127590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1316235110
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