A naturally occuring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms

In addition to guiding proteins to defined genomic loci, DNA can act as an allosteric ligand that influences protein structure and activity. Here we compared genome-wide binding, transcriptional regulation, and, using NMR, the conformation of two glucocorticoid receptor (GR) isoforms that differ by...

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Bibliographic Details
Main Authors: Thomas-Chollier, Morgane, Watson, Lisa C., Cooper, Samantha B., Pufall, Miles A., Liu, Jennifer S., Borzym, Katja, Vingron, Martin, Yamamoto, Keith R., Meijsing, Sebastiaan H.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816441/
https://ncbi.nlm.nih.gov/pubmed/24127590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1316235110
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