A naturally occuring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms

In addition to guiding proteins to defined genomic loci, DNA can act as an allosteric ligand that influences protein structure and activity. Here we compared genome-wide binding, transcriptional regulation, and, using NMR, the conformation of two glucocorticoid receptor (GR) isoforms that differ by...

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Autori principali: Thomas-Chollier, Morgane, Watson, Lisa C., Cooper, Samantha B., Pufall, Miles A., Liu, Jennifer S., Borzym, Katja, Vingron, Martin, Yamamoto, Keith R., Meijsing, Sebastiaan H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816441/
https://ncbi.nlm.nih.gov/pubmed/24127590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1316235110
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