A naturally occuring insertion of a single amino acid rewires transcriptional regulation by glucocorticoid receptor isoforms

In addition to guiding proteins to defined genomic loci, DNA can act as an allosteric ligand that influences protein structure and activity. Here we compared genome-wide binding, transcriptional regulation, and, using NMR, the conformation of two glucocorticoid receptor (GR) isoforms that differ by...

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Main Authors: Thomas-Chollier, Morgane, Watson, Lisa C., Cooper, Samantha B., Pufall, Miles A., Liu, Jennifer S., Borzym, Katja, Vingron, Martin, Yamamoto, Keith R., Meijsing, Sebastiaan H.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2013
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816441/
https://ncbi.nlm.nih.gov/pubmed/24127590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1316235110
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