Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity

The glucocorticoid receptor (GR) binds as a homodimer to genomic response elements, which have particular sequence and shape characteristics. Here we show that the nucleotides directly flanking the core-binding site, differ depending on the strength of GR-dependent activation of nearby genes. Our st...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nat Commun
Hauptverfasser: Schöne, Stefanie, Jurk, Marcel, Helabad, Mahdi Bagherpoor, Dror, Iris, Lebars, Isabelle, Kieffer, Bruno, Imhof, Petra, Rohs, Remo, Vingron, Martin, Thomas-Chollier, Morgane, Meijsing, Sebastiaan H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025757/
https://ncbi.nlm.nih.gov/pubmed/27581526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12621
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge