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Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity
The glucocorticoid receptor (GR) binds as a homodimer to genomic response elements, which have particular sequence and shape characteristics. Here we show that the nucleotides directly flanking the core-binding site, differ depending on the strength of GR-dependent activation of nearby genes. Our st...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5025757/ https://ncbi.nlm.nih.gov/pubmed/27581526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12621 |
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