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Sequences flanking the core-binding site modulate glucocorticoid receptor structure and activity

The glucocorticoid receptor (GR) binds as a homodimer to genomic response elements, which have particular sequence and shape characteristics. Here we show that the nucleotides directly flanking the core-binding site, differ depending on the strength of GR-dependent activation of nearby genes. Our st...

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書目詳細資料
發表在:Nat Commun
Main Authors: Schöne, Stefanie, Jurk, Marcel, Helabad, Mahdi Bagherpoor, Dror, Iris, Lebars, Isabelle, Kieffer, Bruno, Imhof, Petra, Rohs, Remo, Vingron, Martin, Thomas-Chollier, Morgane, Meijsing, Sebastiaan H.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025757/
https://ncbi.nlm.nih.gov/pubmed/27581526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12621
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