Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation

The genomic loci bound by the glucocorticoid receptor (GR), a hormone-activated transcription factor, show little overlap between cell types. To study the role of chromatin and sequence in specifying where GR binds, we used Bayesian modeling within the universe of accessible chromatin. Taken togethe...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Love, Michael I., Huska, Matthew R., Jurk, Marcel, Schöpflin, Robert, Starick, Stephan R., Schwahn, Kevin, Cooper, Samantha B., Yamamoto, Keith R., Thomas-Chollier, Morgane, Vingron, Martin, Meijsing, Sebastiaan H.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
Matèries:
Gene regulation, Chromatin and Epigenetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389550/
https://ncbi.nlm.nih.gov/pubmed/27903902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1163
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