Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation

The genomic loci bound by the glucocorticoid receptor (GR), a hormone-activated transcription factor, show little overlap between cell types. To study the role of chromatin and sequence in specifying where GR binds, we used Bayesian modeling within the universe of accessible chromatin. Taken togethe...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Love, Michael I., Huska, Matthew R., Jurk, Marcel, Schöpflin, Robert, Starick, Stephan R., Schwahn, Kevin, Cooper, Samantha B., Yamamoto, Keith R., Thomas-Chollier, Morgane, Vingron, Martin, Meijsing, Sebastiaan H.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
Sujets:
Gene regulation, Chromatin and Epigenetics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389550/
https://ncbi.nlm.nih.gov/pubmed/27903902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1163
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