Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation

The genomic loci bound by the glucocorticoid receptor (GR), a hormone-activated transcription factor, show little overlap between cell types. To study the role of chromatin and sequence in specifying where GR binds, we used Bayesian modeling within the universe of accessible chromatin. Taken togethe...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Love, Michael I., Huska, Matthew R., Jurk, Marcel, Schöpflin, Robert, Starick, Stephan R., Schwahn, Kevin, Cooper, Samantha B., Yamamoto, Keith R., Thomas-Chollier, Morgane, Vingron, Martin, Meijsing, Sebastiaan H.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389550/
https://ncbi.nlm.nih.gov/pubmed/27903902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1163
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