Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation

The genomic loci bound by the glucocorticoid receptor (GR), a hormone-activated transcription factor, show little overlap between cell types. To study the role of chromatin and sequence in specifying where GR binds, we used Bayesian modeling within the universe of accessible chromatin. Taken togethe...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Love, Michael I., Huska, Matthew R., Jurk, Marcel, Schöpflin, Robert, Starick, Stephan R., Schwahn, Kevin, Cooper, Samantha B., Yamamoto, Keith R., Thomas-Chollier, Morgane, Vingron, Martin, Meijsing, Sebastiaan H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Gene regulation, Chromatin and Epigenetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389550/
https://ncbi.nlm.nih.gov/pubmed/27903902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1163
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