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Systematic in vitro profiling of off-target affinity, cleavage and efficiency for CRISPR enzymes
CRISPR RNA-guided endonucleases (RGEs) cut or direct activities to specific genomic loci, yet each has off-target activities that are often unpredictable. We developed a pair of simple in vitro assays to systematically measure the DNA-binding specificity (Spec-seq), catalytic activity specificity (S...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7229833/ https://ncbi.nlm.nih.gov/pubmed/32315032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa231 |
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