The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508

Por Baumli, Sonja, Hole, Alison J., Noble, Martin E. M., Endicott, Jane A.
Publicado em 2012

Computational analyses of the surface properties of protein–protein interfaces

Por Gruber, Jan, Zawaira, Alexander, Saunders, Rhodri, Barrett, C. Paul, Noble, Martin E. M.
Publicado em 2007

A new crystal form of Lys48-linked diubiquitin

Por Trempe, Jean-François, Brown, Nicholas R., Noble, Martin E. M., Endicott, Jane A.
Publicado em 2010

An Inhibitor’s-Eye View of the ATP-Binding Site of CDKs in Different Regulatory States

Por Echalier, Aude, Hole, Alison J., Lolli, Graziano, Endicott, Jane A., Noble, Martin E. M.
Publicado em 2014

Investigation of the catalytic triad of arylamine N-acetyltransferases: essential residues required for acetyl transfer to arylamines

Por Sandy, James, Mushtaq, Adeel, Holton, Simon J., Schartau, Pamela, Noble, Martin E. M., Sim, Edith
Publicado em 2005

Distinctive Properties of the Hyaluronan-binding Domain in the Lymphatic Endothelial Receptor Lyve-1 and Their Implications for Receptor Function

Por Banerji, Suneale, Hide, Branwen R. S., James, John R., Noble, Martin E. M., Jackson, David G.
Publicado em 2010

The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor b

Por Baumli, Sonja, Hole, Alison J., Wang, Lan-Zhen, Noble, Martin E.M., Endicott, Jane A.
Publicado em 2012

Structural Analysis of the Interactions Between Paxillin LD Motifs and α-Parvin

Por Lorenz, Sonja, Vakonakis, Ioannis, Lowe, Edward D., Campbell, Iain D., Noble, Martin E.M., Hoellerer, Maria K.
Publicado em 2008

Structure of Mesorhizobium loti arylamine N-acetyltransferase 1

Por Holton, Simon J., Dairou, Julien, Sandy, James, Rodrigues-Lima, Fernando, Dupret, Jean-Marie, Noble, Martin E. M., Sim, Edith
Publicado em 2004

Structure of HsaD, a steroid-degrading hydrolase, from Mycobacterium tuberculosis

Por Lack, Nathan, Lowe, Edward D., Liu, Jie, Eltis, Lindsay D., Noble, Martin E. M., Sim, Edith, Westwood, Isaac M.
Publicado em 2007

CDK1 structures reveal conserved and unique features of the essential cell cycle CDK

Por Brown, Nicholas R., Korolchuk, Svitlana, Martin, Mathew P., Stanley, Will A., Moukhametzianov, Rouslan, Noble, Martin E. M., Endicott, Jane A.
Publicado no Nat Commun (2015)

Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase

Por Westwood, Isaac M., Holton, Simon J., Rodrigues-Lima, Fernando, Dupret, Jean-Marie, Bhakta, Sanjib, Noble, Martin E. M., Sim, Edith
Publicado em 2005

Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain

Por Trempe, Jean-François, Brown, Nicholas R, Lowe, Edward D, Gordon, Colin, Campbell, Iain D, Noble, Martin E M, Endicott, Jane A
Publicado em 2005

Structure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12

Por Riedinger, Christiane, Boehringer, Jonas, Trempe, Jean-Francois, Lowe, Edward D., Brown, Nicholas R., Gehring, Kalle, Noble, Martin E. M., Gordon, Colin, Endicott, Jane A.
Publicado em 2010

Comparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity

Por Hole, Alison J., Baumli, Sonja, Shao, Hao, Shi, Shenhua, Huang, Shiliang, Pepper, Chris, Fischer, Peter M., Wang, Shudong, Endicott, Jane A., Noble, Martin E.
Publicado em 2012

Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation

Por Boehringer, Jonas, Riedinger, Christiane, Paraskevopoulos, Konstantinos, Johnson, Eachan O. D., Lowe, Edward D., Khoudian, Christina, Smith, Dominique, Noble, Martin E. M., Gordon, Colin, Endicott, Jane A.
Publicado em 2012

Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design

Por Tan, Yaw Sing, Reeks, Judith, Brown, Christopher J., Thean, Dawn, Ferrer Gago, Fernando Jose, Yuen, Tsz Ying, Goh, Eunice Tze Leng, Lee, Xue Er Cheryl, Jennings, Claire E., Joseph, Thomas L., Lakshminarayanan, Rajamani, Lane, David P., Noble, Martin E. M., Verma, Chandra S.
Publicado no J Phys Chem Lett (2016)

Identification and Characterization of an Irreversible Inhibitor of CDK2

Por Anscombe, Elizabeth, Meschini, Elisa, Mora-Vidal, Regina, Martin, Mathew P., Staunton, David, Geitmann, Matthis, Danielson, U. Helena, Stanley, Will A., Wang, Lan Z., Reuillon, Tristan, Golding, Bernard T., Cano, Celine, Newell, David R., Noble, Martin E.M., Wedge, Stephen R., Endicott, Jane A., Griffin, Roger J.
Publicado no Chem Biol (2015)