Peptide, Peptidomimetic, and Small-molecule Antagonists of the p53–HDM2 Protein–Protein Interaction

Por Fischer, Peter M.
Publicado em 2006

Tell Abu al-Kharaz in the Jordan Valley

Por Fischer, Peter M.
Publicado em 2014

Three-Dimensional Pharmacophore Design and Biochemical Screening Identifies Substituted 1,2,4-Triazoles as Inhibitors of the Annexin A2–S100A10 Protein Interaction

Por Reddy, Tummala R K, Li, Chan, Fischer, Peter M, Dekker, Lodewijk V
Publicado em 2012

Design, synthesis and SAR exploration of tri-substituted 1,2,4-triazoles as inhibitors of the annexin A2–S100A10 protein interaction

Por Reddy, Tummala R.K., Li, Chan, Guo, Xiaoxia, Fischer, Peter M., Dekker, Lodewijk V.
Publicado em 2014

Mutations in a translation initiation factor identify target of a memory-enhancing compound

Por Sekine, Yusuke, Zyryanova, Alisa, Crespillo-Casado, Ana, Fischer, Peter M., Harding, Heather P., Ron, David
Publicado no Science (2015)

Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1

Por Jadhav, Gopal P., Kaur, Ishwinder, Maryati, Maryati, Airhihen, Blessing, Fischer, Peter M., Winkler, G. Sebastiaan
Publicado no Bioorg Med Chem Lett (2015)

Design, Synthesis, and Structure−Activity Relationship Exploration of 1-Substituted 4-Aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one Analogues as Inhibitors of the Annexin A2−S100A10...

Por Reddy, Tummala R. K., Li, Chan, Guo, Xiaoxia, Myrvang, Helene K., Fischer, Peter M., Dekker, Lodewijk V.
Publicado em 2011

Synthesis and in Vitro and in Vivo Characterization of Highly β(1)-Selective β-Adrenoceptor Partial Agonists

Por Mistry, Shailesh N., Baker, Jillian G, Fischer, Peter M, Hill, Stephen J, Gardiner, Sheila M, Kellam, Barrie
Publicado em 2013

5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2()

Por Dickens, Michael P., Roxburgh, Patricia, Hock, Andreas, Mezna, Mokdad, Kellam, Barrie, Vousden, Karen H., Fischer, Peter M.
Publicado em 2013

A fluorescence-based assay suitable for quantitative analysis of deadenylase enzyme activity

Por Maryati, Maryati, Kaur, Ishwinder, Jadhav, Gopal P., Olotu-Umoren, Loyin, Oveh, Blessing, Hashmi, Lubna, Fischer, Peter M., Winkler, G. Sebastiaan
Publicado em 2014

Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design

Por Kontopidis, George, Wu, Su-Ying, Zheleva, Daniella I., Taylor, Paul, McInnes, Campbell, Lane, David P., Fischer, Peter M., Walkinshaw, Malcolm D.
Publicado em 2005

A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine

Por Walsby, Elisabeth, Pratt, Guy, Shao, Hao, Abbas, Abdullah Y., Fischer, Peter M., Bradshaw, Tracey D., Brennan, Paul, Fegan, Chris, Wang, Shudong, Pepper, Chris
Publicado em 2013

Comparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity

Por Hole, Alison J., Baumli, Sonja, Shao, Hao, Shi, Shenhua, Huang, Shiliang, Pepper, Chris, Fischer, Peter M., Wang, Shudong, Endicott, Jane A., Noble, Martin E.
Publicado em 2012

Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines

Por Zgair, Atheer, Wong, Jonathan CM, Lee, Jong Bong, Mistry, Jatin, Sivak, Olena, Wasan, Kishor M, Hennig, Ivo M, Barrett, David A, Constantinescu, Cris S, Fischer, Peter M, Gershkovich, Pavel
Publicado no Am J Transl Res (2016)

Targeting RNA transcription and translation in ovarian cancer cells with pharmacological inhibitor CDKI-73

Por Lam, Frankie, Abbas, Abdullahi Y., Shao, Hao, Teo, Theodosia, Adams, Julian, Li, Peng, Bradshaw, Tracey D., Fischer, Peter M., Walsby, Elisabeth, Pepper, Chris, Chen, Yi, Ding, Jian, Wang, Shudong
Publicado em 2014

Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation

Por Soukarieh, Fadi, Nowicki, Matthew W., Bastide, Amandine, Pöyry, Tuija, Jones, Carolyn, Dudek, Kate, Patwardhan, Geetanjali, Meullenet, François, Oldham, Neil J., Walkinshaw, Malcolm D., Willis, Anne E., Fischer, Peter M.
Publicado no Eur J Med Chem (2016)

Synthetic lethal targeting of DNA double strand break repair deficient cells by human apurinic/apyrimidinic endonuclease (APE1) inhibitors

Por Sultana, Rebeka, McNeill, Daniel R., Abbotts, Rachel, Mohammed, Mohammed Z., Zdzienicka, Małgorzata Z., Qutob, Haitham, Seedhouse, Claire, Laughton, Charles A., Fischer, Peter M., Patel, Poulam M., Wilson, David M., Madhusudan, Srinivasan
Publicado em 2012

Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure–Activity Relationship, and Anticancer Acti...

Por Shao, Hao, Shi, Shenhua, Huang, Shiliang, Hole, Alison J., Abbas, Abdullahi Y., Baumli, Sonja, Liu, Xiangrui, Lam, Frankie, Foley, David W., Fischer, Peter M., Noble, Martin, Endicott, Jane A., Pepper, Chris, Wang, Shudong
Publicado em 2013