27th Annual GP2A Medicinal Chemistry Conference

por Mistry, Shailesh N., Marchand, Pascal, Kellam, Barrie
Publicado no Pharmaceuticals (Basel) (2019)

The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRs

por Vernall, Andrea J, Hill, Stephen J, Kellam, Barrie
Publicado em 2014

Allosteric interactions at adenosine A1 and A3 receptors: new insights into the role of small molecules and receptor dimerization

por Hill, Stephen J, May, Lauren T, Kellam, Barrie, Woolard, Jeanette
Publicado em 2014

Alkylation of Staurosporine to Derive a Kinase Probe for Fluorescence Applications

por Disney, Alexander J. M., Kellam, Barrie, Dekker, Lodewijk V.
Publicado no ChemMedChem (2016)

Effect of a toggle switch mutation in TM6 of the human adenosine A(3) receptor on Gi protein-dependent signalling and Gi-independent receptor internalization

por Stoddart, Leigh A, Kellam, Barrie, Briddon, Stephen J, Hill, Stephen J
Publicado em 2014

NanoBiT Complementation to Monitor Agonist-Induced Adenosine A(1) Receptor Internalization

por Soave, Mark, Kellam, Barrie, Woolard, Jeanette, Briddon, Stephen J., Hill, Stephen J.
Publicado no SLAS Discov (2019)

Kinetic analysis of antagonist-occupied adenosine-A(3) receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism

por Corriden, Ross, Kilpatrick, Laura E., Kellam, Barrie, Briddon, Stephen J., Hill, Stephen J.
Publicado em 2014

Synthesis of New DPP-4 Inhibitors Based on a Novel Tricyclic Scaffold

por Schwehm, Carolin, Li, Jin, Song, Hongmei, Hu, Xiao, Kellam, Barrie, Stocks, Michael J.
Publicado no ACS Med Chem Lett (2015)

A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A(3) Receptor in Living Cells

por Arruda, Maria Augusta, Stoddart, Leigh A., Gherbi, Karolina, Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.
Publicado no Front Pharmacol (2017)

Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A(1) receptor ligands

por Baker, Jillian G, Middleton, Richard, Adams, Luke, May, Lauren T, Briddon, Stephen J, Kellam, Barrie, Hill, Stephen J
Publicado em 2010

Fragment Screening at Adenosine-A(3) Receptors in Living Cells Using a Fluorescence-Based Binding Assay

por Stoddart, Leigh A., Vernall, Andrea J., Denman, Jessica L., Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.
Publicado em 2012

Synthesis and in Vitro and in Vivo Characterization of Highly β(1)-Selective β-Adrenoceptor Partial Agonists

por Mistry, Shailesh N., Baker, Jillian G, Fischer, Peter M, Hill, Stephen J, Gardiner, Sheila M, Kellam, Barrie
Publicado em 2013

Adenosine-A(3) receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes

por Corriden, Ross, Self, Tim, Akong-Moore, Kathryn, Nizet, Victor, Kellam, Barrie, Briddon, Stephen J, Hill, Stephen J
Publicado em 2013

5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2()

por Dickens, Michael P., Roxburgh, Patricia, Hock, Andreas, Mezna, Mokdad, Kellam, Barrie, Vousden, Karen H., Fischer, Peter M.
Publicado em 2013

Monitoring Allosteric Interactions with CXCR4 Using NanoBiT Conjugated Nanobodies

por Soave, Mark, Heukers, Raimond, Kellam, Barrie, Woolard, Jeanette, Smit, Martine J., Briddon, Stephen J., Hill, Stephen J.
Publicado no Cell Chem Biol (2020)

Synthesis and Characterization of High-Affinity 4,4-Difluoro-4-bora-3a,4a-diaza-s-indacene-Labeled Fluorescent Ligands for Human β-Adrenoceptors

por Baker, Jillian G., Adams, Luke A., Salchow, Karolina, Mistry, Shailesh N., Middleton, Richard J., Hill, Stephen J., Kellam, Barrie
Publicado em 2011

Subtype selective fluorescent ligands based on ICI 118,551 to study the human β2‐adrenoceptor in CRISPR/Cas9 genome‐edited HEK293T cells at low expression levels

por Goulding, Joëlle, Mistry, Sarah J., Soave, Mark, Woolard, Jeanette, Briddon, Stephen J., White, Carl W., Kellam, Barrie, Hill, Stephen J.
Publicado no Pharmacol Res Perspect (2021)

Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y(2) Receptor Based on AR-C118925

por Conroy, Sean, Kindon, Nicholas D., Glenn, Jacqueline, Stoddart, Leigh A., Lewis, Richard J., Hill, Stephen J., Kellam, Barrie, Stocks, Michael J.
Publicado no J Med Chem (2018)

Using Esterase Selectivity to Determine the In Vivo Duration of Systemic Availability and Abolish Systemic Side Effects of Topical β-Blockers

por Baker, Jillian G., Fromont, Christophe, Bruder, Marjorie, Thompson, Kevin S. J., Kellam, Barrie, Hill, Stephen J., Gardiner, Sheila M., Fischer, Peter M.
Publicado no ACS Pharmacol Transl Sci (2020)

Correction to Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y(2) Receptor Based on AR-C118925

por Conroy, Sean, Kindon, Nicholas D., Glenn, Jacqueline, Stoddart, Leigh A., Lewis, Richard J., Hill, Stephen J., Kellam, Barrie, Stocks, Michael J.
Publicado no J Med Chem (2018)