Subtype selective fluorescent ligands based on ICI 118,551 to study the human β2‐adrenoceptor in CRISPR/Cas9 genome‐edited HEK293T cells at low expression levels

Fluorescent ligand technologies have proved to be powerful tools to improve our understanding of ligand‐receptor interactions. Here we have characterized a small focused library of nine fluorescent ligands based on the highly selective β(2)‐adrenoceptor (β(2)AR) antagonist ICI 118,551. The majority...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Goulding, Joëlle, Mistry, Sarah J., Soave, Mark, Woolard, Jeanette, Briddon, Stephen J., White, Carl W., Kellam, Barrie, Hill, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8130569/
https://ncbi.nlm.nih.gov/pubmed/34003582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.779
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