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Use of a new proximity assay (NanoBRET) to investigate the ligand‐binding characteristics of three fluorescent ligands to the human β (1)‐adrenoceptor expressed in HEK‐293 cells
Previous research has indicated that allosteric interactions across the dimer interface of β (1)‐adrenoceptors may be responsible for a secondary low affinity binding conformation. Here we have investigated the potential for probe dependence, in the determination of antagonist pK(i) values at the hu...
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| Publicado en: | Pharmacol Res Perspect |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4988514/ https://ncbi.nlm.nih.gov/pubmed/27588207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.250 |
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