Visualizing Ligand Binding to a GPCR In Vivo Using NanoBRET

The therapeutic action of a drug depends on its ability to engage with its molecular target in vivo. However, current drug discovery strategies quantify drug levels within organs rather than determining the binding of drugs directly to their specific molecular targets in vivo. This is a particular p...

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Publicado en:iScience
Main Authors: Alcobia, Diana C., Ziegler, Alexandra I., Kondrashov, Alexander, Comeo, Eleonora, Mistry, Sarah, Kellam, Barrie, Chang, Aeson, Woolard, Jeanette, Hill, Stephen J., Sloan, Erica K.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137713/
https://ncbi.nlm.nih.gov/pubmed/30240618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.08.006
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