Pharmacology under the microscope: the use of fluorescence correlation spectroscopy to determine the properties of ligand–receptor complexes

Por Briddon, Stephen J., Hill, Stephen J.
Publicado em 2007

Micro-pharmacokinetics: Quantifying local drug concentration at live cell membranes

Por Gherbi, Karolina, Briddon, Stephen J., Charlton, Steven J.
Publicado no Sci Rep (2018)

Bimolecular fluorescence complementation: lighting up seven transmembrane domain receptor signalling networks

Por Rose, Rachel H, Briddon, Stephen J, Holliday, Nicholas D
Publicado em 2010

A novel fluorescent histamine H(1) receptor antagonist demonstrates the advantage of using fluorescence correlation spectroscopy to study the binding of lipophilic ligands

Por Rose, Rachel H, Briddon, Stephen J, Hill, Stephen J
Publicado em 2012

Fluorescence correlation spectroscopy, combined with bimolecular fluorescence complementation, reveals the effects of β-arrestin complexes and endocytic targeting on the membrane m...

Por Kilpatrick, Laura E., Briddon, Stephen J., Holliday, Nicholas D.
Publicado em 2012

The Effect of Allosteric Modulators on the Kinetics of Agonist-G Protein-Coupled Receptor Interactions in Single Living Cells

Por May, Lauren T., Self, Tim J., Briddon, Stephen J., Hill, Stephen J.
Publicado em 2010

Effect of a toggle switch mutation in TM6 of the human adenosine A(3) receptor on Gi protein-dependent signalling and Gi-independent receptor internalization

Por Stoddart, Leigh A, Kellam, Barrie, Briddon, Stephen J, Hill, Stephen J
Publicado em 2014

Kinetic analysis of antagonist-occupied adenosine-A(3) receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism

Por Corriden, Ross, Kilpatrick, Laura E., Kellam, Barrie, Briddon, Stephen J., Hill, Stephen J.
Publicado em 2014

Negative cooperativity across β(1)-adrenoceptor homodimers provides insights into the nature of the secondary low-affinity CGP 12177 β1-adrenoceptor binding conformation

Por Gherbi, Karolina, May, Lauren T., Baker, Jillian G., Briddon, Stephen J., Hill, Stephen J.
Publicado no FASEB J (2015)

Allosteric interactions across native adenosine-A(3) receptor homodimers: quantification using single-cell ligand-binding kinetics

Por May, Lauren T., Bridge, Lloyd J., Stoddart, Leigh A., Briddon, Stephen J., Hill, Stephen J.
Publicado em 2011

A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A(3) Receptor in Living Cells

Por Arruda, Maria Augusta, Stoddart, Leigh A., Gherbi, Karolina, Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.
Publicado no Front Pharmacol (2017)

Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A(1) receptor ligands

Por Baker, Jillian G, Middleton, Richard, Adams, Luke, May, Lauren T, Briddon, Stephen J, Kellam, Barrie, Hill, Stephen J
Publicado em 2010

Fragment Screening at Adenosine-A(3) Receptors in Living Cells Using a Fluorescence-Based Binding Assay

Por Stoddart, Leigh A., Vernall, Andrea J., Denman, Jessica L., Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.
Publicado em 2012

Adenosine-A(3) receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes

Por Corriden, Ross, Self, Tim, Akong-Moore, Kathryn, Nizet, Victor, Kellam, Barrie, Briddon, Stephen J, Hill, Stephen J
Publicado em 2013

Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu

Por Ayling, Laura J., Briddon, Stephen J., Halls, Michelle L., Hammond, Gerald R. V., Vaca, Luis, Pacheco, Jonathan, Hill, Stephen J., Cooper, Dermot M. F.
Publicado em 2012

Development of novel fluorescent histamine H(1)-receptor antagonists to study ligand-binding kinetics in living cells

Por Stoddart, Leigh A., Vernall, Andrea J., Bouzo-Lorenzo, Monica, Bosma, Reggie, Kooistra, Albert J., de Graaf, Chris, Vischer, Henry F., Leurs, Rob, Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.
Publicado no Sci Rep (2018)

Real-time analysis of the binding of fluorescent VEGF(165)a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor compl...

Por Kilpatrick, Laura E., Friedman-Ohana, Rachel, Alcobia, Diana C., Riching, Kristin, Peach, Chloe J., Wheal, Amanda J., Briddon, Stephen J., Robers, Matthew B., Zimmerman, Kris, Machleidt, Thomas, Wood, Keith V., Woolard, Jeanette, Hill, Stephen J.
Publicado no Biochem Pharmacol (2017)